Esentra 120mg Injection contains Denosumab as its active ingredient and is primarily used to treat conditions involving bone loss, such as osteoporosis and bone complications arising from certain cancers. It is commonly prescribed to postmenopausal women with osteoporosis at high risk of fractures and to patients with bone metastases from solid tumors or multiple myeloma. Denosumab functions by targeting and inhibiting the RANK ligand, a key mediator in the activation of osteoclasts—the cells responsible for bone resorption. By suppressing their activity, Denosumab helps to reduce bone breakdown, increase bone mineral density, and lower the risk of fractures.
While this treatment is effective, it is not suitable for everyone. Individuals who have known allergies to Denosumab or any of its ingredients should avoid its use. The medication also requires adequate calcium and vitamin D levels before and during treatment to help prevent hypocalcemia, a potential side effect. For patients with moderate kidney impairment, renal function may need to be monitored regularly due to the risk of worsening calcium balance.
Esentra 120mg is not intended for use in children or adolescents, as its safety and efficacy have not been established in those under 18 years of age. Additionally, it should be used with caution in individuals with pre-existing hypoparathyroidism, as they are more susceptible to disturbances in calcium regulation during treatment. Always consult your healthcare provider before starting this therapy to determine whether it is appropriate based on your overall health condition.
Esentra 120mg Injection is used in the treatment of the following condition:
Osteoporosis
Bone loss due to hormonal therapy in breast or prostate cancer
Multiple myeloma (cancer affects plasma cells in the bone marrow)
Bone metastases (cancer that spreads to bone)
Esentra 120mg Injection delivers its therapeutic benefits by targeting and inhibiting RANK ligands—proteins that play a central role in bone resorption. Through this mechanism, the medication effectively reduces the activity of osteoclasts, the cells responsible for breaking down bone tissue. As a result, Esentra slows bone loss, helps preserve existing bone structure, and promotes the accumulation of bone mineral density (BMD).
This action not only strengthens bones but also significantly reduces the risk of fractures, particularly in individuals with osteoporosis or cancer-related bone deterioration. Improved BMD serves as a key indicator of enhanced bone strength, which contributes to better skeletal stability. For patients living with conditions that weaken bones, these effects translate to fewer fractures, reduced pain, and improved physical mobility—ultimately supporting a better quality of life throughout the course of treatment.
Inform your doctor about all the medications you are currently taking or have recently taken, including prescription drugs, over-the-counter medicines, vitamin or nutritional supplements, and any herbal products. This is crucial because certain medications may interact with Esentra 120mg Injection, potentially reducing its effectiveness or increasing the risk of adverse effects. Providing a complete list of your medications helps your doctor assess possible interactions and make necessary adjustments to ensure the safety and effectiveness of your treatment plan.
Esentra 120mg Injection is administered by a qualified healthcare professional as a subcutaneous injection. The specific dosage and duration of the treatment are tailored to the individual’s medical condition, treatment goals, and how well they respond to the medication. It is essential that this injection is not self-administered. Your healthcare provider will monitor your progress and adjust the treatment regimen if necessary to ensure optimal safety and effectiveness.
Esentra 120mg Injection should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
Do not freeze it.
Keep in the original package.
Keep away from light, moisture, and heat.
Keep away from children and pets.
Avoid taking double doses for missed doses
Serious:
Osteonecrosis of the jaw (severe necrosis or death of jaw cells)
Atypical femoral fractures
Hypocalcemia (low blood calcium levels)
Common:
Injection site reactions
Back pain
Musculoskeletal pain
Infections
Abdominal pain
Headache
Hypophosphatemia (low blood phosphate levels)
Breast Feeding
Consult Your Doctor
Whether Esentra 120mg Injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.
Alcohol
Unsafe
It is generally recommended to avoid or limit alcohol consumption while taking Esentra 120mg Injection. Alcohol can interact with this medication, potentially increasing the risk of side effects.
Liver
Consult Your Doctor
Esentra 120mg Injection is primarily metabolized in the liver, and its safety has not been extensively studied in individuals with severe liver impairment. It is crucial to communicate any pre-existing liver conditions or changes in liver function to your healthcare provider to ensure this medication's safe and effective use.
Lungs
Consult Your Doctor
If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Esentra 120mg Injection.
Driving
Unsafe
Patients receiving Esentra 120mg Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.
Pregnancy
Consult Your Doctor
The safety of using Esentra 120mg Injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.
Fact Box of ESSENTRA 120
Molecule Name: Denosumab
Therapeutic Class: Anti-resorptive agent
Pharmacological Class: Monoclonal Antibodies
Indications:
1. Osteoporosis
2. Bone loss due to hormonal therapy in breast or prostate cancer
3. Multiple myeloma
4. Bone metastases
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