Pangraf 0.5 is a prescription medicine that contains tacrolimus. It is an immunosuppressant which is generally used to prevent the rejection of an organ after a transplant. It is basically the one that saves the life of the transplantation over a long period by controlling the immune system, which is the major culprit to the damage of the transplanted organ.
This instruction provides easy, to, understand, physiologically correct data relating to the drug Pangraf 0.5, how it works, its usage, safety issues, and requirements for observation.
What Is Pangraf 0.5?
The main ingredient of Pangraf 0.5 is tacrolimus, which belongs to one of the categories of drugs known as calcineurin inhibitors. These medications are intended to weaken the immune system pathways responsible for the rejection of the transplanted organ.
Basic Drug Information
| Parameter | Details |
| Generic name | Tacrolimus |
| Brand name | Pangraf 0.5 |
| Drug class | Immunosuppressant Calcineurin Inhibitors |
| Dosage form | Oral capsule |
| Strength | Pangraf 0.5 mg |
| Primary use | Prevention of organ rejection |
Why Is Tacrolimus Prescribed After Organ Transplant?
After an organ transplantation, the immune system still considers the new organ as foreign, wants to get rid of it and thus, attacks it. If this immune response is not controlled, it can lead to the rejection of the new organ either in an acute or chronic manner and finally, the graft may fail completely.
Tacrolimus limits the immune response just enough to keep the new organ working properly i.e. without the immune system being completely turned off.
Doctors usually recommend Pangraf 0.5 for use after:
- Kidney transplant
- Liver transplant
- Heart transplant
Moreover, tacrolimus can be administered in certain instances of autoimmune diseases when the condition is resistant to other treatments but the main indication of the drug is still immunosuppression after a transplant.
How Does Pangraf 0.5 Work?
Tacrolimus interferes with the immune system at cellular level; which means it works on each cell.
Here is the Simplified Mechanism of Action of Pangraf 0.5 immunosuppressant-
Tacrolimus attaches to proteins inside the cell of the immune system.
By doing so it interferes with the calcineurin activity because the enzyme binds to the region where the complex is formed.
Activation of T cells is limited thereby less rejection is brought about by the immune system.
This way Pangraf 0.5 is one of the drugs that help to keep the immune system balanced, the organ transplanted is protected while the body still retains its basic anti-infection mechanisms.
Dosage and How to Take Pangraf 0.5
Tacrolimus is an example of drugs with a narrow therapeutic index, in other words, the issue lies in the difference between a dose which is effective and a dose which is toxic and the difference is small.
Important Administration Guidelines You must follow,
- Take Pangraf 0.5 at the same time every day
- If not otherwise instructed, take it on an empty stomach
- Do not break the capsule nor mix the contents with other substances
- You should never stop or change your dose without consulting your doctor
Physicians check regularly on the blood levels of tacrolimus to assure that it is safe and effective. Even the smallest change in dose can bring about a significant change in blood levels.
Monitoring During Treatment
Those on Pangraf 0.5 (Tacrolimus) should have a series of investigations done regularly which include:
- Tacrolimus trough levels
- Kidney function tests
- Liver function tests
- Blood sugar levels
- Blood pressure monitoring
Such surveillance should not be understood as a problem but rather as a standard and indispensable part of safe long-term therapy.
Possible Side Effects of Pangraf 0.5
Most of the time, people who use Pangraf 0.5 do not experience major problems as long as the levels in the blood are kept within the therapeutic range.
Most Frequent Side Effects can be
- Uncontrollable hand movements or tremors
- Headache
- Hypertension
- Stomach related problems
Less Frequent but Still Notable Side Effects
- Blood glucose levels increase
- Changes in kidney function
- Increased risk of infections
- Hair loss with prolonged use
Any abnormal and persistent symptoms should be disclosed to the doctor immediately.
Precautions and Safety Information
Once you decide on taking tacrolimus, you should talk to the doctor if you:
- Have had kidney disease before
- Suffer from diabetes or high blood sugar
- Have had infections
- Have liver problems
As an immune suppressant, Pangraf 0.5 patients are encouraged to wash their hands properly and keep away from infection exposure that is not necessary.
Food and Drug Interactions
Some foods and medicines can change the levels of tacrolimus in your body dramatically. Here are foods and drugs that needs to be avoided while you are taking Pangraf 0.5:
Grapefruit or grapefruit juice
Unapproved herbal supplements
Certain antibiotics and antifungal medicines
Over-the-counter painkillers without the prescription of doctor
Your doctor will inform you of any other precautions that need to be taken. It is always good to talk with your transplant doctor if you want to start a new drug or a supplement.
Pangraf 0.5 Price in India
Pangraf 0.5 price can be different due to location, supplier, and availability. You can get it at the lowest price from Medfast, and we ensure quick delivery to your doorstep.
Product: Pangraf 0.5 mg Capsule
Estimated Price Range: ₹350 – ₹650 (per strip, may vary)
Where to order Pangraf from: Medfast.net
Medicines for transplants should be kept in the right way and be of genuine quality. Purchasing from a trustworthy pharmacy such as Medfast in India will give you quality and the right handling.
Why Is Long-Term Adherence Important?
Organ transplantation should not be treated as a one-off event, it actually entails a lifelong commitment to follow the prescribed medication regimen and have regular check-ups.
Pangraf 0.5 is one of the essential parts that will help to keep the organ safe and graft survival possible over the long term. There is a danger of organ rejection that can be caused by missing your doses or if you stop taking medication without a doctor’s guidance.
Conclusion
Pangraf 0.5 (Tacrolimus) is one of the indispensable drugs in post transplant care. This medication drastically reduces the risk of organ rejection and is a great help to the survival of the transplant in the long term, provided that the patient takes it properly and undergoes regular check ups.
Patients are obliged to follow the doctor’s orders regarding medication, attend check ups, avoid taking unapproved drugs, or make any changes to their diet. With the doctor’s proper assistance, tacrolimus will remain a reliable and effective immunosuppressive therapy.
Frequently Asked Questions (FAQs)
1. How long do transplant patients need to take Pangraf 0.5?
Probably, patients will be required to take tacrolimus for a considerable period. Though it is possible to lower the doses, the therapy must not be discontinued unless a doctor’s instruction is given.
2. What should I do if I forget to take a dose of Pangraf 0.5?
If you’ve missed the dose so whenever you remember take your medicine right away. If it is near the time of your next dose, then leave the missed one. Taking twice the dose is prohibited.
3. Why are blood tests done so frequently?
The amount of tacrolimus in the body varies due to factors like food, metabolism, stress, and drug interactions. For safety purposes and to keep the tacrolimus level in check regular blood tests must be done.
4. Is Pangraf 0.5 safe to be used during pregnancy?
Several female transplant patients, who were on tacrolimus, have given birth to healthy babies, however, it needs the supervision of a specialist doctor who may instruct you if you can take it and gives you the dose recommendation.
5. May I take vitamins if I am on tacrolimus therapy?
Only if your doctor gives the green light. Certain supplements may interfere with drug absorption, so it is important to consult the doctor.
6. What is Pangraf 0.5?
Pangraf 0.5 (Tacrolimus) is one of the indispensable drugs in post transplant care. This medication drastically reduces the risk of organ rejection and is a great help to the survival of the transplant in the long term, provided that the patient takes it properly and undergoes regular check ups.
