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PANGRAF 0.5

TACROLIMUS 0.5MG

MRP	:	~~MRP ₹216.93~~
Price	:	₹185.00
You Save	:	₹31.93 (14.72%)

10 capsule(s) in a strip

SKU: 209 Categories: Kidney Speciality Drugs, Nephrology Tags: NEPHROLOGY, NORMAL CHAIN Brand: MANKIND

Pangraf 0.5mg Capsule contains Tacrolimus, an active substance classified as an immunosuppressant and belonging to the calcineurin inhibitors group of medications. Its primary use is in conjunction with other medicines to prevent organ transplant rejection in individuals who have undergone a liver, kidney, heart, or other organ transplant. It works by controlling the body’s immune response, thereby enabling the acceptance of the transplanted organ.

You should not take Pangraf 0.5mg Capsule if you have a known allergy to tacrolimus or any of its other ingredients. It is crucial to inform your physician if you are allergic to any antibiotic group. Before starting treatment, also inform your doctor if you have a history of liver or heart disease. Immediately notify your physician if you experience any concerning symptoms after taking this medicine, such as fever, unexplained bruising under the skin (appearing as red dots), unusual tiredness, confusion, yellowing of the skin or eyes (jaundice), reduced urine output, vision loss, or seizures.

While taking Pangraf 0.5mg Capsule, it is important to limit your exposure to sunlight and UV light. This can be achieved by wearing appropriate protective clothing and using sunscreen with a high sun protection factor. This precaution is necessary due to the potential risk of developing malignant skin changes associated with immunosuppressive therapy. This medicine may also cause diarrhea; if you experience diarrhea for more than a day, inform your physician. Finally, if you require any vaccinations, always consult your doctor beforehand

Pangraf 0.5 uses:

Prevent organ transplant rejections.

Pangraf capsule achieves its immunosuppressive effects by precisely interfering with critical processes within the immune system, particularly those involving T-lymphocytes. The active ingredient, Tacrolimus, functions by first binding to an intracellular protein known as FKBP-12 (FK506-binding protein).

This binding leads to the formation of a complex called tacrolimus-FKBP. This complex then proceeds to inhibit the action of calcineurin phosphatase. Calcineurin is a vital enzyme within T-cells, responsible for activating a key transcription factor necessary for T-cell function.

By inhibiting calcineurin, the tacrolimus-FKBP complex prevents the proper signaling pathways required for T-cell activity. This, in turn, effectively inhibits the formation and proliferation of T-cells, and also suppresses the T-helper-cell-dependent B-cell response. Since T-lymphocytes and B-cells are central to the immune system's attack on foreign entities, this targeted inhibition ultimately suppresses the overall immune response, which is crucial for preventing the rejection of a transplanted organ

It is absolutely essential to have a comprehensive discussion with your healthcare provider about all the medicines you are currently taking. This includes not only prescription medications but also over-the-counter medications, any recent vaccinations, nutritional and vitamin supplements, and herbal products. Providing this complete list is crucial because certain medications can interact negatively with Pangraf 0.5mg Capsule. These interactions could potentially reduce the effectiveness of Pangraf, which is vital for preventing organ rejection, and may also lead to undesirable side effects.

Furthermore, while taking Pangraf 0.5mg Capsule, you must avoid consuming grapefruit or grapefruit juice. Grapefruit can significantly interfere with the metabolism of tacrolimus, the active ingredient in Pangraf, potentially leading to dangerously high levels of the medication in your body and increasing the risk of severe side effects.

Your doctor will carefully determine the correct dose and duration of your treatment with Pangraf 0.5mg Capsule. This decision will be meticulously tailored to your specific disease condition, its severity, and other individual factors relevant to your health.

It is paramount that you always take Pangraf 0.5mg Capsule exactly as prescribed by your doctor. To ensure proper absorption and effectiveness, do not open, break, crush, or chew the capsules. Instead, swallow the capsule whole with a full glass of water. For optimal absorption, these capsules should be taken on an empty stomach, meaning either at least 1 hour before a meal or 2 to 3 hours after a meal

Store Pangraf 0.5mg Capsule at (25°C)
keep the capsule away from the reach of children and pets.
If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose.
Do not take a double dose to compensate for a missed dose.

Common

Swelling in the arm or leg
Hair loss
Itchy skin
Constipation, diarrhea
Nausea, vomiting
Anemia
Headache
Cough

Serious

Increased or decreased heartbeats
GI bleeding
Liver Injury
Seizure
Acute kidney failure
Lung infection or respiratory problems

Breast Feeding

Unsafe

Do not consume Pangraf 0.5mg Capsule if you are breastfeeding because this medicine is excreted into breast milk and may cause harmful effects on the body.

Alcohol

Unsafe

It is unsafe to consume alcohol when taking Pangraf 0.5mg Capsule because it may cause excessive drowsiness or liver problems.

Liver

Consult Your Doctor

Pangraf 0.5mg Capsule should be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary for severe liver failure. Inform your doctor if you have liver problems before initiating the therapy.

Lungs

Consult Your Doctor

It is unknown whether Pangraf 0.5mg Capsule can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Driving

Unsafe

Driving vehicles or operating machinery while taking Pangraf 0.5mg Capsule is unsafe because it may cause drowsiness and vision problems.

Pregnancy

Consult Your Doctor

Based on animal studies, Pangraf 0.5mg Capsule can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy or planning to get pregnant before initiating the treatment.