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1 prefilled syringe(s) of 0.6ml
Pegstim 6mg Injection PFS contains Pegfilgrastim, a long-acting form of granulocyte colony-stimulating factor (G-CSF). It is used to reduce the risk and severity of febrile neutropenia, a condition characterized by fever and a dangerously low white blood cell count that often occurs as a side effect of chemotherapy. Pegfilgrastim works by stimulating the bone marrow to produce more neutrophils, a type of white blood cell essential for fighting infections. By increasing the number of these cells, it helps the body better defend itself during periods when the immune system is weakened by cancer treatment.
This medication is also indicated in patients exposed to high-dose radiation, which can severely impair bone marrow function. In such cases, Pegstim aids in preserving the immune system by restoring white blood cell levels, improving the chance of recovery and survival.
Pegfilgrastim is a synthetic protein produced using recombinant DNA technology in E. coli bacteria. It mimics the body’s own natural G-CSF and helps accelerate the recovery of white blood cells after chemotherapy. Since chemotherapy can drastically lower WBC counts, making patients vulnerable to infections, this injection plays a critical role in minimizing complications and maintaining treatment schedules.
Before starting therapy with Pegstim, it’s important to discuss any underlying medical conditions, especially related to the liver, kidneys, or heart, as these may influence the safety or effectiveness of the drug. Additionally, patients should report any unusual symptoms, such as upper abdominal or shoulder pain, which may suggest rare but serious complications like an enlarged spleen or respiratory issues.
Commonly, patients may experience bone or muscle pain following the injection, but these effects are usually manageable. The medication is administered as a single injection under medical supervision, typically once per chemotherapy cycle, and should never be self-administered.
Pegstim 6mg is a prescription PFS Injection, and it is used to treat
Pegstim 6mg Injection PFS functions as a long-acting colony-stimulating factor by targeting hematopoietic (blood-forming) cells in the bone marrow. It binds to specific cell surface receptors on precursor cells, particularly those responsible for producing neutrophils. This receptor binding initiates a cascade of cellular events that stimulate cell division, promote the proliferation of neutrophil precursors, and enhance their maturation.
In addition to increasing the production of neutrophils, Pegstim also activates these cells functionally—making them more effective in combating infections. By doing so, it helps restore immune defense mechanisms that may be compromised during chemotherapy or radiation exposure. This dual action—boosting both quantity and activity of white blood cells—makes Pegstim an essential therapy in preventing neutropenia-related complications in cancer patients.
Make sure to inform your healthcare provider about all medications you are currently taking or have recently taken. This includes prescription drugs, over-the-counter medications, nutritional supplements, vitamins, and any herbal or traditional remedies. Some of these substances may interact with Pegstim 6mg Injection PFS, potentially altering its effectiveness or increasing the risk of side effects. Providing your complete medication history allows your doctor to ensure the treatment is safe and to make any necessary adjustments to your therapy plan.
The Injection will be administered in the fatty tissues just under your skin (subcutaneously) by a qualified healthcare professional in a hospital setting. The dose and frequency of administration will be decided by your doctor based on your disease condition and other factors.
If your physician decides that Pegstim 6mg Injection PFS can be administered at home by you or your caregiver, then read the “Instructions for use” carefully from the package insert that comes with the Injection. Your doctor or other healthcare professionals will train you on self-administration. Do not administer the Injection if you have not been trained and not sure about the administration procedure
Common
Serious
It is unsafe to breastfeed during the treatment with this Pegstim 6mg Injection PFS because it may cause harm to the baby. Please consult your doctor before breastfeeding.
It is unsafe to consume alcohol with Pegstim 6mg Injection. Please consult your doctor for more advice.
It is unknown whether Pegstim 6mg Injection PFS can be administered in patients with liver disorders. Inform your physician if you have any liver problems before starting treatment with this Injection.
It is unknown whether Pegstim 6mg Injection PFS can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
It is unsafe to travel, drive vehicles or operate heavy machinery after taking (1 hour) Pegstim 6mg Injection PFS. Please consult your doctor.
Pegstim 6mg Injection PFS is unsafe when administered during pregnancy because it may cause birth defects in your baby. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Molecule Name: Pegfilgrastim
Therapeutic Class: Hematopoietic
Pharmacological Class: colony-stimulating factors
Indications:
Febrile neutropenia
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