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1 vial(s) of 1.7ml
Xgeva 120mg Injection contains Denosumab, a monoclonal antibody that plays a vital role in bone health management. It is primarily prescribed to prevent skeletal-related events in patients with bone metastases from solid tumors and to manage osteoporosis in postmenopausal women at high risk of fracture. Xgeva works by targeting and inhibiting the RANK ligand, a protein essential for the development and activation of osteoclasts—cells responsible for bone breakdown. By blocking this protein, Xgeva slows bone resorption, enhances bone mass and strength, and lowers the risk of fractures and other bone complications.
This medication is not suitable for individuals with known allergies to Denosumab or any of its ingredients. Because it can cause a drop in blood calcium levels, patients are typically advised to maintain adequate intake of calcium and vitamin D throughout the treatment period. Regular blood tests may be necessary to monitor calcium levels, particularly in patients with kidney issues or those at risk for hypocalcemia.
Xgeva is not intended for use in children or adolescents, as its safety and effectiveness in these populations have not been established. It should also be used with caution in patients who have pre-existing conditions such as hypoparathyroidism, as this may exacerbate calcium imbalances. Always consult your healthcare provider before beginning treatment to ensure it is appropriate for your individual health needs.
Xgeva 120mg Injection is used in the treatment of the following condition:
Xgeva 120mg Injection delivers its therapeutic benefits by targeting and inhibiting the RANK ligand, a protein critical for osteoclast formation and activity—the cells responsible for bone resorption. By suppressing this pathway, Xgeva effectively reduces bone breakdown and loss, leading to a marked improvement in bone mineral density (BMD). This mechanism is particularly valuable for patients with osteoporosis or those suffering from bone metastases, where the balance of bone remodeling is disrupted.
The key therapeutic effects of Xgeva include a significant reduction in fracture risk, especially in areas like the spine, hips, and other bones commonly affected by metastatic disease or osteoporosis. Additionally, the increase in BMD directly correlates with improved bone strength and durability, offering better structural support and mobility for patients.
Beyond physical benefits, the reduction in fracture incidence and bone-related complications can contribute to enhanced patient outcomes, fewer hospitalizations, and a better quality of life. For individuals living with chronic bone conditions or cancer-related bone disease, Xgeva represents a critical component of comprehensive bone health management.
Before starting treatment with Xgeva 120mg Injection, it is important to inform your doctor about all medications and supplements you are currently taking or have recently taken. This includes:
Certain medications may interact with Denosumab (the active ingredient in Xgeva), potentially leading to reduced therapeutic effectiveness or undesirable side effects. These interactions may affect your body’s calcium levels, increase the risk of infections, or impact bone turnover.
To ensure safety and the best therapeutic outcomes, your healthcare provider may adjust your dosage, monitor you more closely, or recommend alternative treatments depending on your medication profile.
Never start or stop any medication while on Xgeva without first consulting your healthcare provider.
Xgeva 120mg Injection is typically administered by a medical professional, often in a hospital or clinical environment, and the process is handled with care to ensure both safety and precision. The medication is given through a subcutaneous injection, and the exact dose along with the treatment duration is determined based on how the patient responds to the therapy and the specific medical condition being addressed. This ensures that the drug exerts its intended effect without unnecessary complications.
Because Xgeva targets bone resorption pathways, maintaining optimal calcium levels during the course of treatment is crucial, so doctors often recommend supplemental calcium and vitamin D. Close supervision is maintained throughout the treatment to detect any signs of imbalance or adverse reaction early. Patients are advised not to self-administer this injection under any circumstance and to stick to the schedule as outlined by their physician to maintain therapeutic consistency
Serious:
Common:
Whether Xgeva 120mg Injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.
It is generally recommended to avoid or limit alcohol consumption while taking Xgeva 120mg Injection. Alcohol can interact with this medication, potentially increasing the risk of side effects.
Xgeva 120mg Injection is primarily metabolized in the liver, and its safety has not been extensively studied in individuals with severe liver impairment. It is crucial to communicate any pre-existing liver conditions or changes in liver function to your healthcare provider to ensure this medication's safe and effective use.
If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Xgeva 120mg Injection.
Patients receiving Xgeva 120mg Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.
The safety of using Xgeva 120mg Injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.
Molecule Name: Denosumab
Therapeutic Class: Anti-resorptive agent
Pharmacological Class: Monoclonal Antibodies
Indications:
1. Osteoporosis
2. Bone loss due to hormonal therapy in breast or prostate cancer
3. Multiple myeloma
4. Bone metastases
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