Bryxta 300mg Injection is an anticancer medication that contains Bevacizumab as its active ingredient. This treatment is designed to inhibit tumor growth. It is prescribed in conjunction with other chemotherapy drugs for the management of metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. Additionally, it is utilized for treating cancers of the ovary, fallopian tube, or primary peritoneal cancer. Effective birth control should be employed during treatment and for at least six months following the final dose. Bryxta 300mg Injection is not advised for adolescents and children under 18 years of age. If you are considering pregnancy soon, consult your doctor regarding the preservation of ovaries, as this medication may lead to fertility issues in women. It is also recommended to refrain from breastfeeding, as this medication may affect growth and development.
Bryxta 300mg Injection is frequently given in combination with other chemotherapy drugs. Common side effects include constipation, loss of appetite, runny nose, fever, skin issues, and weight loss. Prior to commencing treatment with this medication, inform your doctor if you have high blood pressure, elevated blood sugar, gastrointestinal disorders, or heart conditions. This medication should not be administered for 28 days before or after surgery due to its association with poor wound healing and increased bleeding risks. It is advisable to notify your doctor of any dental problems requiring surgery before starting this medication. Should you experience any visual disturbances or confusion, contact your doctor immediately to avoid complications.
Bryxta 300mg Injection is indicated to treat the following conditions:
Glioblastoma multiforme (brain cancer)
Persistent, recurrent, or metastatic breast cancer
Metastatic cervical cancer
Advanced kidney cancer
Metastatic colorectal cancer
Advanced non-small-cell lung cancer
Liver Cancer- Hepatocellular carcinoma
Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer
Bevacizumab is a humanized monoclonal antibody that has been engineered to function as a targeted therapy for the treatment of several advanced cancers. It exerts its effects by specifically binding to a protein known as vascular endothelial growth factor A (VEGF-A), which is found in the lining of blood and lymphatic vessels throughout the body. This action disrupts the interaction between VEGF-A and its receptors, thereby inhibiting the development of blood vessels that provide oxygen and nutrients to tumors. Consequently, it reduces the rate at which cancer progresses.
Bryxta 300 Injection includes 'Bevacizumab', which targets vascular endothelial growth factor (VEGF) present on the surfaces of lymphatic and blood vessels. VEGF promotes the growth of blood vessels within tumors, supplying them with oxygen and nutrients. By inhibiting vascular endothelial growth factor, the supply of oxygen and nutrients to the tumor is restricted, leading to its reduction or halting its growth. Consequently, this aids in the treatment of cancers.
Your doctor or nurse will provide Bryxta 300mg Injection through an intravenous infusion. This infusion must be administered right after the dilution.
Store Bryxta 300mg Injection at 2˚C to 8˚C.
Do not freeze or shake.
Protect from light.
Keep out of reach of children.
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
Headache
Vision changes
Confusion
Severe allergic reactions
High Blood pressure
Delayed wound healing following surgery
Protein in urine
Severe infections
Blood clots in arteries and blood vessels of lungs
Gut perforation
Nosebleeds and bleeding risk
Heart problems with an increase in heart rate
Mouth sores, dryness
Shortness of breath
Common:
Numbness in hands or feet
Weakness and lack of energy
Diarrhoea, nausea, vomiting, abdominal pain
Constipation
Loss of appetite
Weight loss
Changes in taste and speech
Decrease in counts of white blood cells
Fever
Dry skin
Back pain
Breastfeeding - Not Safe
Breastfeeding
Not Safe
It is advised to refrain from breastfeeding for at least 6 months following your treatment with Bryxta 300mg Injection, as this medication may affect your child's growth.
Alcohol - Consult Your Doctor
Alcohol
Consult Your Doctor
Please consult your physician to determine if it is safe to drink alcohol while undergoing treatment with Bryxta 300mg Injection, as there are only limited studies available on this matter.
Liver - Consult Your Doctor
Liver
Consult Your Doctor
Notify your doctor before beginning treatment with Bryxta 300mg Injection if you have any liver conditions to prevent serious side effects.
Lungs - Consult Your Doctor
Lungs
Consult Your Doctor
Make sure to inform your doctor about any lung issues prior to starting treatment with Bryxta 300mg Injection.
Driving - Not Safe
Driving
Not Safe
It is recommended to avoid driving or operating machinery while receiving treatment with Bryxta 300mg Injection, as it may lead to dizziness or drowsiness.
Pregnancy - Not Safe
Pregnancy
Not Safe
Notify your physician before commencing treatment with Bryxta 300mg Injection if you are pregnant or planning to become pregnant, as this medication could potentially harm the unborn child and disrupt blood vessel formation.
Fact Box of Bryxta 300mg Injection
Molecule Name: BEVACIZUMAB
Therapeutic Class: Anticancer
Pharmacological Class: VEGF Inhibitor
Indications:
1. Glioblastoma multiforme (brain cancer)
2. Persistent, recurrent, or metastatic breast cancer
3. Metastatic cervical cancer
4. Advanced kidney cancer
5. Metastatic colorectal cancer
6. Advanced non-small-cell lung cancer
7. Liver Cancer- Hepatocellular carcinoma
8. Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer
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