Apigat 5mg Tablet is a direct oral anticoagulant (DOAC) that belongs to the class of Factor Xa inhibitors, containing the active ingredient Apixaban. It is primarily prescribed for preventing deep vein thrombosis (DVT)—a condition where blood clots form in the veins, typically in the legs—which can lead to pulmonary embolism (PE), a potentially life-threatening condition if the clot travels to the lungs. This medication is commonly used in patients recovering from hip or knee replacement surgeries, where the risk of clot formation is elevated. Additionally, it plays a vital role in reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF), a type of irregular heartbeat that increases the risk of clots forming in the heart.
Certain formulations of this medicine may contain lactose as an inactive component. For individuals with lactose intolerance—a condition in which the body cannot effectively digest lactose, the sugar present in dairy—this can cause symptoms like bloating and abdominal discomfort. If you are lactose intolerant, it is important to inform your physician before beginning treatment with Apigat.
The use of Apigat is contraindicated in patients with hepatic disease associated with coagulopathy and an increased risk of clinically significant bleeding. It is also not recommended in individuals with severe liver impairment. It is essential to disclose to your doctor any history of bleeding disorders, liver or kidney conditions, or other medications you may be taking, including non-prescription drugs, vitamins, and herbal supplements, as these can interact with Apigat and alter its effectiveness or increase the risk of side effects.
One of the potential risks associated with this medication is spinal or epidural hematoma, especially in patients who undergo spinal anesthesia or spinal procedures. This complication can result in long-term or permanent paralysis if not identified and treated promptly. Therefore, it is crucial to notify your healthcare provider if you are scheduled for any surgical or dental procedures. Close monitoring is required for signs of neurological complications, including numbness or tingling in the limbs, weakness, or loss of bladder or bowel control.
Apigat should not be used during pregnancy unless clearly necessary, as it may pose a risk to the unborn baby. Your doctor will likely perform a pregnancy test before starting this treatment. Effective birth control should be used during treatment and for at least two weeks after the last dose to prevent pregnancy. Always consult your doctor regarding the best contraceptive methods during this period
